Sedation with non sedating antihistamines
Moreover, no sedative or other central nervous system effects were observed.
Both enantiomers of fexofenadine hydrochloride displayed approximately equipotent antihistaminic effects.
Fexofenadine hydrochloride inhibited antigen-induced bronchospasm in sensitized guinea pigs and histamine release from peritoneal mast cells in rats.
The clinical significance of these findings is unknown.
In laboratory animals, no anticholinergic or alpha1-adrenergic blocking effects were observed.
Start with lower doses and increase as needed and tolerated. Measure Karbinal ER with an accurate milliliter measuring device.
A household teaspoon is not an accurate measuring device and could lead to overdosage.
Sustained-release: 8 or 12 mg po every 8 to 12 hours. Supplied: Extended Release Cap: 6 mg, 8 mg, 12 mg Liquid/syrup: 2 mg/5 ml Tablet: 2 mg, 4 mg.
Chewable: 2 mg EExtended Release tab: 8 mg, 12 mg, 16 mg Tavist 12 Hour Allergy Tablets: Clemastine fumarate, USP 1.34 mg (equivalent to 1 mg clemastine).
Once-daily fexofenadine appears to offer effective and well-tolerated relief from the symptoms of this illness.
Please see package insert for additional information and possible updates.
Claritin-D 24 Hour Extended Release Tablets should generally be avoided in patients with hepatic insufficiency. Antihistamines compete with histamine for receptor sites on effector cells.