Moreover, no sedative or other central nervous system effects were observed.

sedation with non sedating antihistamines-60

Mechanism of Action Desloratadine is a long-acting tricyclic histamine antagonist with selective H1-receptor histamine antagonist activity.

Receptor binding data indicate that at a concentration of 2–3 ng/m L (7 nanomolar), desloratadine shows significant interaction with the human histamine H1-receptor.

Sustained-release: 8 or 12 mg po every 8 to 12 hours. Supplied: Extended Release Cap: 6 mg, 8 mg, 12 mg Liquid/syrup: 2 mg/5 ml Tablet: 2 mg, 4 mg.

Chewable: 2 mg EExtended Release tab: 8 mg, 12 mg, 16 mg Tavist 12 Hour Allergy Tablets: Clemastine fumarate, USP 1.34 mg (equivalent to 1 mg clemastine).

They are used primarily to treat disorders where abnormal or excessive histamine release by inflammatory cells is thought to underly illness.

This includes conditions such as: Other conditions such as hyper-reactive (vasomotor) rhinitis and pruritus of any cause are commonly treated with antihistamines, although there is little evidence that histamine plays a contributory role.

A pharmacist can provide an appropriate measuring device and can provide instructions for measuring the correct dose.

[see Warnings and Precautions (5.5)] Adults and Adolescents 12 years of age and older: 7.5 m L to 20 m L (6 to 16 mg) every 12 hours Children 2 to 11 years of age (approximately 0.2 to 0.4 mg/kg/day): 2 to 3 years: 3.75 m L to 5 m L (3 to 4 mg) every 12 hours 4 to 5 years: 3.75 m L to 10 m L (3 to 8 mg) every 12 hours 6 to 11 years: 7.5 m L to 15 m L (6 to 12 mg) every 12 hours HOW SUPPLIED: Extended-release oral suspension containing 4 mg carbinoxamine maleate per 5 m L Adult (usual): 4 mg po every 4 to 6 hrs; maximum dose: 24 mg/day.

Seasonal allergic rhinitis: 60 mg orally twice daily or 180 mg once daily.